A Different Presentation of Hodgkin’s Lymphoma; Eosinophilia and Inguinal Localized Giant Mass
Hodgkin’s Lymphoma is a tumor that comprises fewer malignant Hodgkin, Reed-Sternberg cells and variants in the tumor tissue (1-2% of all cells) different from the other hematological and solid tumors. Most of the tumor mass is composed of reactive inflamatory cells (T-B lymphocytes, eosinophils, plasmocytes, mastocytes and neutrophils), stromal cells and connective tissue surrounding the tumor cells. Among them, eosinophils frequently infiltrate Hodgkin’s Lymphoma tissues and the peripheral blood eosinophilia is also a well recognised feature (15%) of this disease. However the prognostic importance of this is still controversial. In the literature some of the studies have reported that eosinophilia has no prognostic significance in Hodgkin’s Lymphoma. However some of them claimed that selective eosinophilia without generalised leucocytosis provided clear survival advantage especially in patients with disseminated disease. Here we report a case diagnosed as Hodgkin’s Lymphoma, mixed cellularity type, presenting with a large mass localized in the inguinal region accompanying with tissue and peripheral blood eosinophilia with generalised leucocytosis who had a good survival .
Keywords: Eosinophilia, giant mass, Hodgkin lymphoma
Keresztes K, Szollosı Z, Sımon Z, Tarkanyı I, Nemes Z, Illes A. Retrospective Analysis of the Prognostic Role of Tissue Eosinophil and Mast Cells in Hodgkin’s Lymphoma. Pathol Oncol Res. 2007;13(3):237-42.
Hudson BV, Linch DC, Macintyre EA et al. Selective peripheral blood eosinophilia associated with survival advantage in Hodgkin's disease (BNLI Report No 31). J Clin Pathol. 1987;40:247-50.
Axdorph U, Porwit-MacDonald A, Grimfors G, Björkholm M. Tissue Eosinophilia in relation to immunopathological and clinical characteristics in Hodgkin’s Disease. Leuk Lymphoma. 2001; 42(5):1055-65.
Wasielewski RV, Seth S, Franklin J et al. Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin’s disease, allowing for known prognostic factors. Blood. 2000;95:1207-13.
Mir R, Anderson J, Strauchen J et al. Hodgkin disease in patients 60 years of age or older: histologic and clinical features of advanced-stage disease. The Cancer and Leukemia Group B. Cancer. 1993;71:1857.
d’Amore ES, Lee CK, Aeppli DM, Levitt SH, Frizzera G. Lack of prognostic value of histopathologic parameters in Hodgkin’s disease, nodular sclerosis type: a study of 123 patients with limited stage disease who had undergone laparotomy and were treated with radiationtherapy. Arch Pathol Lab Med. 1992;116:856.
Güler N, Kelkitli E, Atay H et al. The Relationship of T Helper-2 Pathway Components Interleukin-4, Interleukin-10, Immunoglobulin E, and Eosinophils with Prognostic Markers in Non-Hodgkin Lymphoma: A Case-Control Study. TJH. 2014;31(4):381-7.
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